Association of Pain Sensitization and Conditioned Pain Modulation to Pain Patterns in Knee Osteoarthritis.

ABSTRACT:

Objective

To examine the cross-sectional association of ascending pain mechanisms, implicated in pain sensitization, and descending pain modulation with pain patterns and unpredictability of pain.

Methods

The Multicenter Osteoarthritis Study is a longitudinal cohort of older adults with or at risk of knee osteoarthritis. Peripheral and central ascending pain mechanisms were assessed using quantitative sensory tests, pressure pain thresholds using a handheld pressure algometer (knee/peripheral and wrist/central), and temporal summation using weighted probes (wrist/central). Descending modulation was assessed by conditioned pain modulation using pressure pain thresholds and a forearm ischemia test. Pain patterns were characterized based on responses to the Intermittent and Con

SUBMITTER: Carlesso LC 

PROVIDER: S-EPMC7925701 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature