Crosstalk between endoplasmic reticulum stress and oxidative stress in the progression of diabetic nephropathy.

ABSTRACT: Increasing evidence in substantiating the roles of endoplasmic reticulum stress, oxidative stress, and inflammatory responses and their interplay is evident in various diseases. However, an in-depth mechanistic understanding of the crosstalk between the intracellular stress signaling pathways and inflammatory responses and their participation in disease progression has not yet been explored. Progress has been made in our understanding of the cross talk and integrated stress signaling network between endoplasmic reticulum stress and oxidative stress towards the pathogenesis of diabetic nephropathy. In this present study, we studied the crosstalk between the endoplasmic reticulum stress and oxidative stress by understanding the role of protein disulfide isomerase and endoplasmic reticulum ox

SUBMITTER: Victor P 

PROVIDER: S-EPMC7925747 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature