IgA Levels Are Associated with Coronary Artery Lesions in Kawasaki Disease.

ABSTRACT:

Background and objectives

Kawasaki disease (KD) is an acute systemic vasculitis that affects the coronary arteries. Abnormal immune reactions are thought to contribute to disease pathogenesis. The effect of immunoglobulin (Ig) isotype (IgG, IgA, IgM, and IgE) on inflammatory data and clinical outcomes of patients with KD was examined.

Methods

Ig levels in 241 patients with KD were measured during the acute, subacute, convalescent, and normal phases of the disease.

Results

Compared with reference Ig values, IgG, IgA, and IgM levels were significantly higher in the subacute phase, while IgE levels were elevated in 73.9% (178/241) of patients with KD in all clinical phases. However, high IgE levels were not associated with clinical outcomes, including intravenous immunog

SUBMITTER: Kim JJ 

PROVIDER: S-EPMC7925970 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature