Association between blood pressure and BMI with bladder cancer risk and mortality in 340,000 men in three Swedish cohorts.

ABSTRACT:

Background

The relation between obesity, blood pressure (BP) and bladder cancer (BC) risk and mortality remains unclear, partially due to potential confounding by smoking, the strongest risk factor for BC, and not accounting for tumor stage and grade in such studies. We investigated body mass index (BMI) and BP in relation to BC risk by stage and grade, and BC-specific mortality, including separately among never-smokers aimed at minimizing confounding by smoking.

Methods

We analyzed 338,910 men from three Swedish cohorts, with 4895 incident BC's (940 among never-smokers) during follow-up. Cox regression was used to calculate hazard ratios (HR) and 95% confidence intervals adjusted for smoking status. HRs for BMI and BP were corrected for their regression dilution ratios, cal

SUBMITTER: Teleka S 

PROVIDER: S-EPMC7926028 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature