Neuropeptide Substance P Enhances Skin Wound Healing In Vitro and In Vivo under Hypoxia.

ABSTRACT: Pressure ulcers (PUs) or sores are a secondary complication of diabetic neuropathy and traumatic spinal cord injury (SCI). PUs tend to occur in soft tissues located around bony prominences and may heal slowly or not at all. A common mechanism underlying impaired healing of PUs may be dysfunction of the local neurovascular system including deficiency of essential neuropeptides, such as substance P (SP). Previous studies indicate that disturbance in cutaneous sensory innervation leads to a defect in all stages of wound healing, as is the case after SCI. It is hypothesized that nerve fibers enhance wound healing by promoting initial inflammation via the releasing of neuropeptides such as SP. Therefore, we investigated whether exogenous SP improves skin wound healing using in vitro and in vivo

SUBMITTER: Kumar S 

PROVIDER: S-EPMC7926396 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature