Chromatin Accessibility Is Associated with Artemisinin Biosynthesis Regulation in Artemisia annua.

ABSTRACT: Glandular trichome (GT) is the dominant site for artemisinin production in Artemisia annua. Several critical genes involved in artemisinin biosynthesis are specifically expressed in GT. However, the molecular mechanism of differential gene expression between GT and other tissue types remains elusive. Chromatin accessibility, defined as the degree to which nuclear molecules are able to interact with chromatin DNA, reflects gene expression capacity to a certain extent. Here, we investigated and compared the landscape of chromatin accessibility in Artemisia annua leaf and GT using the Assay for Transposase-Accessible Chromatin using sequencing (ATAC-seq) technique. We identified 5413 GT high accessible and 4045 GT low accessible regions, and these GT high accessible regions may contribute to

SUBMITTER: Zhou L 

PROVIDER: S-EPMC7926469 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature