Baicalein Inhibits Streptococcus mutans Biofilms and Dental Caries-Related Virulence Phenotypes.

ABSTRACT: Dental caries, the most common oral disease, is a major public healthcare burden and affects more than three billion people worldwide. The contemporary understanding of the need for a healthy microbiome and the emergence of antimicrobial resistance has resulted in an urgent need to identify compounds that curb the virulence of pathobionts without microbial killing. Through this study, we have demonstrated for the first time that 5,6,7-trihydroxyflavone (Baicalein) significantly downregulates crucial caries-related virulence phenotypes in Streptococcus mutans. Baicalein significantly inhibited biofilm formation by Streptococcus mutans UA159 (MBIC50 = 200 μM), without significant growth inhibition. Notably, these concentrations of baicalein did not affect the commensal S. gordonii. Strikingl

SUBMITTER: Vijayakumar A 

PROVIDER: S-EPMC7926557 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature