MTOR Signaling in Pulmonary Vascular Disease: Pathogenic Role and Therapeutic Target.

ABSTRACT: Pulmonary arterial hypertension (PAH) is a progressive and fatal disease without a cure. The exact pathogenic mechanisms of PAH are complex and poorly understood, yet a number of abnormally expressed genes and regulatory pathways contribute to sustained vasoconstriction and vascular remodeling of the distal pulmonary arteries. Mammalian target of rapamycin (mTOR) is one of the major signaling pathways implicated in regulating cell proliferation, migration, differentiation, and protein synthesis. Here we will describe the canonical mTOR pathway, structural and functional differences between mTOR complexes 1 and 2, as well as the crosstalk with other important signaling cascades in the development of PAH. The pathogenic role of mTOR in pulmonary vascular remodeling and sustained vasoconstric

SUBMITTER: Babicheva A 

PROVIDER: S-EPMC7926633 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature