Taccalonolides: A Novel Class of Microtubule-Stabilizing Anticancer Agents.

ABSTRACT: Microtubule stabilizing agents, such as paclitaxel, docetaxel, and cabazitaxel have been among the most used chemotherapeutic agents in the last decades for the treatment of a wide range of cancers in the clinic. One of the concerns that limit their use in clinical practice is their intrinsic and acquired drug resistance, which is common to most anti-cancer chemotherapeutics. Taccalonolides are a new class of microtubule stabilizers isolated from the roots of a few species in the genus of Tacca. In early studies, taccalonolides demonstrated different effects on interphase and mitotic microtubules from those of paclitaxel and laulimalide suggesting a unique mechanism of action. This prompts the exploration of new taccalonolides with various functionalities through the identification of mino

SUBMITTER: Chen X 

PROVIDER: S-EPMC7926778 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature