Vitamin D Deficiency Cause Gender Specific Alterations of Renal Arterial Function in a Rodent Model.

ABSTRACT: Vitamin D deficiency shows positive correlation to cardiovascular risk, which might be influenced by gender specific features. Our goal was to examine the effect of Vitamin D supplementation and Vitamin D deficiency in male and female rats on an important hypertension target organ, the renal artery. Female and male Wistar rats were fed with Vitamin D reduced chow for eight weeks to induce hypovitaminosis. Another group of animals received normal chow with further supplementation to reach optimal serum vitamin levels. Isolated renal arteries of Vitamin D deficient female rats showed increased phenylephrine-induced contraction. In all experimental groups, both indomethacin and selective cyclooxygenase-2 inhibition (NS398) decreased the phenylephrine-induced contraction. Angiotensin II-induce

SUBMITTER: Sipos M 

PROVIDER: S-EPMC7926839 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature