On the Prevalence and Potential Functionality of an Intrinsic Disorder in the MERS-CoV Proteome.

ABSTRACT: Middle East respiratory syndrome is a severe respiratory illness caused by an infectious coronavirus. This virus is associated with a high mortality rate, but there is as of yet no effective vaccine or antibody available for human immunity/treatment. Drug design relies on understanding the 3D structures of viral proteins; however, arriving at such understanding is difficult for intrinsically disordered proteins, whose disorder-dependent functions are key to the virus's biology. Disorder is suggested to provide viral proteins with highly flexible structures and diverse functions that are utilized when invading host organisms and adjusting to new habitats. To date, the functional roles of intrinsically disordered proteins in the mechanisms of MERS-CoV pathogenesis, transmission, and treatmen

SUBMITTER: Alshehri MA 

PROVIDER: S-EPMC7926987 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature