In Vitro and In Vivo Studies on HPMA-Based Polymeric Micelles Loaded with Curcumin.

ABSTRACT: Curcumin-loaded polymeric micelles composed of poly(ethylene glycol)-b-poly(N-2-benzoyloxypropyl methacrylamide) (mPEG-b-p(HPMA-Bz)) were prepared to solubilize and improve the pharmacokinetics of curcumin. Curcumin-loaded micelles were prepared by a nanoprecipitation method using mPEG_5kDa-b-p(HPMA-Bz) copolymers with varying molecular weight of the hydrophobic block (5.2, 10.0, and 17.1 kDa). At equal curcumin loading, micelles composed of mPEG_5kDa-b-p(HPMA-Bz)_17.1kDa showed better curcumin retention in both phosphate-buffered saline (PBS) and plasma at 37 °C than micelles based on block copolymers with smaller hydrophobic blocks. No change in micelle size was observed during 24 h incubation in plasma using asymmetrical f

SUBMITTER: Bagheri M 

PROVIDER: S-EPMC7927141 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature