A detailed Monte Carlo evaluation of ¹⁹²Ir dose enhancement for gold nanoparticles and comparison with experimentally measured dose enhancements.

ABSTRACT: Gold nanoparticles (GNPs) have been studied extensively as promising radiation dose enhancing agents. In the current study, the dose enhancement effect of GNPs for Ir-192 HDR brachytherapy is studied using Monte Carlo N-Particle code, version 6.2 (MCNP6.2) and compared with experimental results obtained using Burlin cavity theory formalism. The Ir-192 source is verified using TG-43 parameters and dose enhancement factors (DEFs) from GNPs are simulated for three different mass percentages of gold in the GNP solution. These results are compared to DEFs previously reported experimentally by our group (Bassiri et al 2019 Med. Phys.) for a GNP-containing volume in an apparatus designed in-house to measure dose enhancement with GNPs for high dose rate (HDR) Ir-192 brachytherapy. An HDR Ir-192 Mi

SUBMITTER: Gray T 

PROVIDER: S-EPMC7927155 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature