The application of optical coherence tomography angiography in Alzheimer's disease: A systematic review.

ABSTRACT:

Introduction

Discovering non-invasive and easily acquired biomarkers that are conducive to the accurate diagnosis of dementia is an urgent area of ongoing clinical research. One promising approach is retinal imaging, as there is homology between retinal and cerebral vasculature. Recently, optical coherence tomography angiography (OCT-A) has emerged as a promising new technology for imaging the microvasculature of the retina.

Methods

A systematic review and meta-analysis was conducted to examine the application of OCT-A in dementia.

Results

Fourteen studies assessing OCT-A in preclinical Alzheimer's disease (AD), mild cognitive impairment, or AD were included. Exploratory meta-analyses revealed a significant increase in the foveal avascular zone area and a significant

SUBMITTER: Rifai OM 

PROVIDER: S-EPMC7927164 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature