Growth disadvantage associated with centrosome amplification drives population-level centriole number homeostasis.

ABSTRACT: The centriole duplication cycle normally ensures that centriole number is maintained at two centrioles per G1 cell. However, some circumstances can result in an aberrant increase in centriole number-a phenotype that is particularly prevalent in several types of cancer. Following an artificial increase in centriole number without tetraploidization due to transient overexpression of the kinase PLK4, human cells return to a normal centriole number during the proliferation of the population. We examine the mechanisms responsible for this return to normal centriole number at the population level in human retinal pigment epithelial cells. We find that the return to normal centriole number in the population of induced cells cannot be explained by limited duplication of centrioles, instability of

SUBMITTER: Sala R 

PROVIDER: S-EPMC7927180 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature