Heart Failure Prevention in Older Patients Using Intensive Blood Pressure Reduction: Potential Role of Diuretics.

ABSTRACT:

Objectives

This study assessed the potential role of differential diuretic drugs in preventing incident acute decompensated heart failure (ADHF) in the SPRINT (Systolic Blood Pressure Intervention Trial) study.

Background

SPRINT showed that intensive blood pressure reduction in older patients (50 to 97 years of age) resulted in 36% fewer incident cases of ADHF. However, some investigators have questioned whether this was due merely to intergroup differences in diuretic medications.

Methods

Detailed use of medication data prospectively collected throughout the trial were examined.

Results

ADHF events occurred in 173 of 9,361 participants. Diuretic medication increased in both arms from screening to baseline visit (from 45% to 50% in the standard arm; and from 43

SUBMITTER: Upadhya B 

PROVIDER: S-EPMC7927202 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature