Recruitment of γδ T cells to the lesion via the CCL2/CCR2 signaling after spinal cord injury.

ABSTRACT:

Background

Immune cell infiltration and neuroinflammation are heavily associated with spinal cord injury (SCI). C-C motif chemokine ligand 2/C-C chemokine receptor type 2 (CCL2/CCR2) axis has been identified as a critical role player during the invasion of immune cells to lesions in many diseases. γδ T cells, a subgroup of T cells, manage the course of inflammation response in various diseases; however, it remains unknown whether γδ T cells are recruited to injury site through CCL2/CCR2 signaling and exert the regulation effect on neuroinflammation after SCI.

Methods

Basso Mouse Scale (BMS), regularity index, cadence, max contact area, and motor-evoked potential testing (MEP) were measured to determine the neurological function recovery after spinal cord injury. Nissl staini

SUBMITTER: Xu P 

PROVIDER: S-EPMC7927238 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature