The Cholinergic Basal Forebrain Links Auditory Stimuli with Delayed Reinforcement to Support Learning.

ABSTRACT: Animals learn to fear conditioned sound stimuli (CSs) that accompany aversive unconditioned stimuli (USs). Auditory cortex (ACx) circuits reorganize to support auditory fear learning when CS-evoked activity temporally overlaps with US-evoked acetylcholine release from the basal forebrain. Here we describe robust fear learning and acetylcholine-dependent ACx plasticity even when the US is delayed by several seconds following CS offset. A 5-s CS-US gap was not bridged by persistent CS-evoked spiking throughout the trace period. Instead, within minutes following the start of conditioning, optogenetically identified basal forebrain neurons that encode the aversive US scaled up responses to the CS and increased functional coupling with the ACx. Over several days of conditioning, bulk imaging of

SUBMITTER: Guo W 

PROVIDER: S-EPMC7927272 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature