Individual-specific functional connectome biomarkers predict schizophrenia positive symptoms during adolescent brain maturation.

ABSTRACT: Even with an overarching functional dysconnectivity model of adolescent-onset schizophrenia (AOS), there have been no functional connectome (FC) biomarkers identified for predicting patients' specific symptom domains. Adolescence is a period of dramatic brain maturation, with substantial interindividual variability in brain anatomy. However, existing group-level hypotheses of AOS lack precision in terms of neuroanatomical boundaries. This study aimed to identify individual-specific FC biomarkers associated with schizophrenic symptom manifestation during adolescent brain maturation. We used a reliable individual-level cortical parcellation approach to map functional brain regions in each subject, that were then used to identify FC biomarkers for predicting dimension-specific psychotic sympt

SUBMITTER: Fan YS 

PROVIDER: S-EPMC7927287 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature