Differential spatial patterns of structural connectivity of amygdala nuclei with orbitofrontal cortex.

ABSTRACT: The orbitofrontal cortex (OFC)-amygdala circuit is critical to goal-directed behavior, learning, and valuation. However, our understanding of the OFC-amygdala connections that support these emergent processes is hampered by our reliance on the primate literature and insufficient knowledge regarding the connectivity patterns between regions of OFC and amygdala nuclei, each of which is differentially involved in these processes in humans. Thus, we examined structural connectivity between different OFC regions and four amygdala nuclei in healthy adults (n = 1,053) using diffusion-based anatomical networks and probabilistic tractography in four conceptually distinct ways. First, we identified the OFC regions that connect with each nucleus. Second, we identified the OFC regions that were more l

SUBMITTER: Matyi MA 

PROVIDER: S-EPMC7927308 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature