Modeling muscle function using experimentally determined subject-specific muscle properties.

ABSTRACT: Muscle models are commonly based on intrinsic properties pooled across a number of individuals, often from a different species, and rarely validated against directly measured muscle forces. Here we use a rich data set of rat medial gastrocnemius muscle forces recorded during in-situ and in-vivo isometric, isotonic, and cyclic contractions to test the accuracy of forces predicted using Hill-type muscle models. We identified force-length and force-velocity parameters for each individual, and used either these subject-specific intrinsic properties, or population-averaged properties within the models. The modeled forces for cyclic in-vivo and in-situ contractions matched with measured muscle-tendon forces with r² between 0.70 and 0.86, and root-mean square errors (RMSE) of 0.10 to 0

SUBMITTER: Wakeling JM 

PROVIDER: S-EPMC7927351 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature