A metabolite-specific 3D stack-of-spiral bSSFP sequence for improved lactate imaging in hyperpolarized [1-¹³ C]pyruvate studies on a 3T clinical scanner.

ABSTRACT:

Purpose

The balanced steady-state free precession sequence has been previously explored to improve the efficient use of nonrecoverable hyperpolarized ¹³C magnetization, but suffers from poor spectral selectivity and long acquisition time. The purpose of this study was to develop a novel metabolite-specific 3D bSSFP ("MS-3DSSFP") sequence with stack-of-spiral readouts for improved lactate imaging in hyperpolarized [1-¹³ C]pyruvate studies on a clinical 3T scanner.

Methods

Simulations were performed to evaluate the spectral response of the MS-3DSSFP sequence. Thermal ¹³C phantom experiments were performed to validate the MS-3DSSFP sequence. In vivo hyperpolarized [1-¹³ C], pyruvate studies were performed to compare the MS-3DSSFP sequ

SUBMITTER: Tang S 

PROVIDER: S-EPMC7927572 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature