Impact of pathogen-reduction technologies on COVID-19 convalescent plasma potency.

ABSTRACT: Pathogen reduction technologies (PRT) have been recommended by many regulatory authorities to minimize the residual risk of transfusion-transmitted infections associated with COVID19 convalescent plasma. While its impact on safety and its cost-effectiveness are nowadays well proven, there is theoretical concern that PRT could impact efficacy of convalescent plasma by altering concentration and/or function of the neutralizing antibodies (nAb). We review here the evidence supporting a lack of significant detrimental effect from PRTs on nAbs.

SUBMITTER: Focosi D 

PROVIDER: S-EPMC7927574 | biostudies-literature |

REPOSITORIES: biostudies-literature