Intraoperative Assessment and Photothermal Ablation of the Tumor Margins Using Gold Nanoparticles.

ABSTRACT: Surgical resection is commonly used for therapeutic management of different solid tumors and is regarded as a primary standard of care procedure, but precise localization of tumor margins is a major intraoperative challenge. Herein, a generalized method by optimizing gold nanoparticles for intraoperative detection and photothermal ablation of tumor margins is introduced. These nanoparticles are detectable by highly sensitive surface-enhanced Raman scattering imaging. This non-invasive technique assists in delineating the two surgically challenged tumors in live mice with orthotopic colon or ovarian tumors. Any remaining residual tumors are also ablated by using post-surgical adjuvant photothermaltherapy (aPTT), which results in microscale heat generation due to interaction of these nanopar

SUBMITTER: Wei Q 

PROVIDER: S-EPMC7927626 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature