HIV and pericardial fat are associated with abnormal cardiac structure and function among Ugandans.

ABSTRACT:

Objectives

To examine the relationship between pericardial fat (PCF) and cardiac structure and function among HIV-infected patients in the sub-Saharan African country of Uganda. People living with HIV (PLHIV) have altered fat distribution and an elevated risk for heart failure. Whether altered quantity and radiodensity of fat surrounding the heart relates to cardiac dysfunction in this population is unknown.

Methods

One hundred HIV-positive Ugandans on antiretroviral therapy were compared with 100 age and sex-matched HIV-negative Ugandans; all were >45 years old with >1 cardiovascular disease risk factor. Subjects underwent ECG-gated non-contrast cardiac CT and transthoracic echocardiography with speckle tracking strain imaging. Multivariable linear and logistic regression m

SUBMITTER: Buggey J 

PROVIDER: S-EPMC7927634 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature