Epigenetic Dysregulation of Myeloproliferative Neoplasms.

ABSTRACT: This article reviews the genetic data on epigenetic modifying mutations in myeloproliferative neoplasms and their clinical implications, preclinical studies exploring our current understanding of how mutations in epigenetic modifying proteins cooperate with myeloproliferative neoplasms drivers to promote disease progression, and recent advances in novel therapeutics supporting the role of targeting epigenetic pathways to treat fibrotic progression.

SUBMITTER: Dunbar A 

PROVIDER: S-EPMC7927771 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature