Unknown

Dataset Information

0

KPC-53, a KPC-3 Variant of Clinical Origin Associated with Reduced Susceptibility to Ceftazidime-Avibactam.

ABSTRACT: This study reports on the characterization of a Klebsiella pneumoniae clinical isolate showing high-level resistance to ceftazidime-avibactam associated with the production of KPC-53, a KPC-3 variant exhibiting a Leu167Glu168 duplication in the Ω-loop and a loss of carbapenemase activity. Whole-genome sequencing (WGS) revealed the presence of two copies of bla KPC-53, located on a pKpQIL-like plasmid and on a plasmid prophage of the Siphoviridae family, respectively. The present findings provide new insights into the mechanisms of resistance to ceftazidime-avibactam.

SUBMITTER: Di Pilato V 

PROVIDER: S-EPMC7927837 | biostudies-literature |

REPOSITORIES: biostudies-literature

Json Xml

Similar Datasets

Unknown KPC-50 Confers Resistance to Ceftazidime-Avibactam Associated with Reduced Carbapenemase Activity.
| S-EPMC7526841 | biostudies-literature
Unknown Identification of a Novel Ceftazidime-Avibactam-Resistant KPC-2 Variant, KPC-123, in <i>Citrobacter koseri</i> Following Ceftazidime-Avibactam Treatment.
| S-EPMC9251512 | biostudies-literature
Unknown Phenotypic, biochemical and genetic analysis of KPC-41, a KPC-3 variant conferring resistance to ceftazidime-avibactam and exhibiting reduced carbapenemase activity.
| S-EPMC6879233 | biostudies-literature
Unknown Characterization of KPC-82, a KPC-2 Variant Conferring Resistance to Ceftazidime-Avibactam in a Carbapenem-Nonsusceptible Clinical Isolate of Citrobacter koseri.
| S-EPMC8218621 | biostudies-literature
Unknown Patient-to-Patient Transmission of Klebsiella pneumoniae Carbapenemase Variants with Reduced Ceftazidime-Avibactam Susceptibility.
| S-EPMC6761506 | biostudies-literature
Unknown Emergence of a KPC-90 Variant that Confers Resistance to Ceftazidime-Avibactam in an ST463 Carbapenem-Resistant Pseudomonas aeruginosa Strain.
| S-EPMC8754116 | biostudies-literature
Unknown Ceftazidime-Avibactam Susceptibility Breakpoints against Enterobacteriaceae and Pseudomonas aeruginosa.
| S-EPMC6201065 | biostudies-literature
Unknown In vitro antimicrobial susceptibility of clinical respiratory isolates to ceftazidime-avibactam and comparators (2016-2018).
| S-EPMC8220879 | biostudies-literature
Unknown Emergence of a KPC Variant Conferring Resistance to Ceftazidime-Avibactam in a Widespread ST11 Carbapenem-Resistant <i>Klebsiella pneumoniae</i> Clone in China.
| S-EPMC8415713 | biostudies-literature
Unknown Mutations in porin LamB contribute to ceftazidime-avibactam resistance in KPC-producing <i>Klebsiella pneumoniae</i>.
| S-EPMC8567916 | biostudies-literature