Ontology highlight
ABSTRACT:
SUBMITTER: Zandi K
PROVIDER: S-EPMC7927863 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Zandi Keivan K Amblard Franck F Musall Katie K Downs-Bowen Jessica J Kleinbard Ruby R Oo Adrian A Cao Dongdong D Liang Bo B Russell Olivia O OO McBrayer Tamara T Bassit Leda L Kim Baek B Schinazi Raymond F RF
Antimicrobial agents and chemotherapy 20201216 1
Coronavirus disease 2019 (COVID-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or CoV-2). Some reports claimed certain nucleoside analogs to be active against CoV-2 and thus needed confirmation. Here, we evaluated a panel of compounds and identified novel nucleoside analogs with antiviral activity against CoV-2 and HCoV-OC43 while ruling out others. Of significance, sofosbuvir demonstrated no antiviral effect against CoV-2, and its triphosphate did ...[more]