The Impact of Circulating Antibody on Group B Streptococcus Intestinal Colonization and Invasive Disease.

ABSTRACT: Gastrointestinal (GI) colonization with group B Streptococcus (GBS) is an important precursor to late-onset (LO) disease in infants. The host-pathogen interactions that mediate progression to invasive disease remain unknown due, in part, to a paucity of robust model systems. Passively acquired maternal GBS-specific antibodies protect newborns from early-onset disease, yet their impact on GI colonization and LO disease is unexplored. Using murine models of both perinatal and postnatal GBS acquisition, we assessed the kinetics of GBS GI colonization, progression to invasive disease, and the role of GBS-specific IgG production in exposed offspring and juvenile mice at age 12 and 14 days, respectively. We defined LO disease as >7 days of life in the perinatal model. We studied the impact of ma

SUBMITTER: Vaz MJ 

PROVIDER: S-EPMC7927928 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature