Progression of Alzheimer's Disease by Self-Reported Cancer History in the Alzheimer's Disease Neuroimaging Initiative.

ABSTRACT:

Background

Cross-sectional studies suggest self-reported cancer history is associated with decreased risk of Alzheimer's disease (AD). However, little is known about how self-reported cancer affects longitudinal AD progression, the primary outcome in clinical trials and observational studies.

Objective

To determine self-reported cancer history's effect on longitudinal AD progression in an observational study.

Methods

We utilized data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to evaluate progression to AD by self-reported all-cancer, breast, prostate, colorectal, or non-melanoma skin cancer history. Linear mixed effects models were used to examine baseline differences and rates of progression on the Alzheimer's Disease Assessment Scale-Cognitive Subsc

SUBMITTER: Fowler ME 

PROVIDER: S-EPMC7928167 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature