HiPSCs for predictive modelling of neurodegenerative diseases: dreaming the possible.

ABSTRACT: Human induced pluripotent stem cells (hiPSCs) were first generated in 2007, but the full translational potential of this valuable tool has yet to be realized. The potential applications of hiPSCs are especially relevant to neurology, as brain cells from patients are rarely available for research. hiPSCs from individuals with neuropsychiatric or neurodegenerative diseases have facilitated biological and multi-omics studies as well as large-scale screening of chemical libraries. However, researchers are struggling to improve the scalability, reproducibility and quality of this descriptive disease modelling. Addressing these limitations will be the first step towards a new era in hiPSC research - that of predictive disease modelling - involving the correlation and integration of in vitro expe

SUBMITTER: Rivetti di Val Cervo P 

PROVIDER: S-EPMC7928200 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature