Morphological changes of intracranial pressure quantifies vasodilatory effect of verapamil to treat cerebral vasospasm.

ABSTRACT:

Introduction

After aneurysmal subarachnoid hemorrhage (SAH), both proximal and distal cerebral vasospasm can contribute to the development of delayed cerebral ischemia. Intra-arterial (IA) vasodilators are a mainstay of treatment for distal arterial vasospasm, but no methods of assessing the efficacy of interventions in real time have been established.

Objective

To introduce a new method for continuous intraprocedural assessment of endovascular treatment for cerebral vasospasm.

Methods

The premise of our approach was that distal cerebral arterial changes induce a consistent pattern in the morphological changes of intracranial pressure (ICP) pulse. This premise was demonstrated using a published algorithm in previous papers. In this study, we applied the algorithm to c

SUBMITTER: Liu X 

PROVIDER: S-EPMC7928236 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature