Meiotic Heterogeneity of Trivalent Structure and Interchromosomal Effect in Blastocysts With Robertsonian Translocations.

ABSTRACT:

Background

Robertsonian translocations are common structural rearrangements and confer an increased genetic reproductive risk due to the formation of trivalent structure during meiosis. Studies on trivalent structure show meiotic heterogeneity between different translocation carriers, although the factors causing heterogeneity have not been well elaborated in blastocysts. It is also not yet known whether interchromosomal effect (ICE) phenomenon occurs in comparison with suitable non-translocation control patients. Herein, we aimed to evaluate the factors that cause meiotic heterogeneity of trivalent structure and the ICE phenomenon.

Methods

We designed a retrospective study, comprising 217 Robertsonian translocation carriers and 134 patients with the risk of transmitting mon

SUBMITTER: Zhang S 

PROVIDER: S-EPMC7928295 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature