Analyses of cancer incidence and other morbidities in neutron irradiated B6CF1 mice.

ABSTRACT: The Department of Energy conduced ten large-scale neutron irradiation experiments at Argonne National Laboratory between 1972 and 1989. Using a new approach to utilize experimental controls to determine whether a cross comparison between experiments was appropriate, we amalgamated data on neutron exposures to discover that fractionation significantly improved overall survival. A more detailed investigation showed that fractionation only had a significant impact on the death hazard for animals that died from solid tumors, but did not significantly impact any other causes of death. Additionally, we compared the effects of sex, age first irradiated, and radiation fractionation on neutron irradiated mice versus cobalt 60 gamma irradiated mice and found that solid tumors were the most common ca

SUBMITTER: Zander A 

PROVIDER: S-EPMC7928494 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature