The Impact of Vaccination on Coronavirus Disease 2019 (COVID-19) Outbreaks in the United States.

ABSTRACT:

Background

Global vaccine development efforts have been accelerated in response to the devastating coronavirus disease 2019 (COVID-19) pandemic. We evaluated the impact of a 2-dose COVID-19 vaccination campaign on reducing incidence, hospitalizations, and deaths in the United States.

Methods

We developed an agent-based model of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission and parameterized it with US demographics and age-specific COVID-19 outcomes. Healthcare workers and high-risk individuals were prioritized for vaccination, whereas children under 18 years of age were not vaccinated. We considered a vaccine efficacy of 95% against disease following 2 doses administered 21 days apart achieving 40% vaccine coverage of the overall population within

SUBMITTER: Moghadas SM 

PROVIDER: S-EPMC7929033 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature