Repurposing approved drugs for cancer therapy.

ABSTRACT:

Background

Many drugs approved for other indications can control the growth of tumor cells and limit adverse events (AE).

Data sources

Literature searches with keywords 'repurposing and cancer' books, websites: https://clinicaltrials.gov/, for drug structures: https://pubchem.ncbi.nlm.nih.gov/.

Areas of agreement

Introducing approved drugs, such as those developed to treat diabetes (Metformin) or inflammation (Thalidomide), identified to have cytostatic activity, can enhance chemotherapy or even replace more cytotoxic drugs. Also, anti-inflammatory compounds, cytokines and inhibitors of proteolysis can be used to control the side effects of chemo- and immuno-therapies or as second-line treatments for tumors resistant to kinase inhibitors (KI). Drugs specifically devel

SUBMITTER: Schein CH 

PROVIDER: S-EPMC7929227 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature