Tumor-derived ILT4 induces T cell senescence and suppresses tumor immunity.

ABSTRACT:

Background

Current immunotherapies including checkpoint blockade therapy have limited success rates in certain types of cancers. Identification of alternative checkpoint molecules for the development of effective strategies for tumor immunotherapy is urgently needed. Immunoglobulin-like transcript 4 (ILT4) is an immunosuppressive molecule expressed in both myeloid innate cells and malignant tumor cells. However, the role of tumor-derived ILT4 in regulating cancer biology and tumor immunity remains unclear.

Methods

ILT4 expression in tumor cells and patient samples was determined by real-time PCR, flow cytometry, and immunohistochemistry. T cell senescence induced by tumor was evaluated using multiple markers and assays. Moreover, metabolic enzyme and signaling molecule expre

SUBMITTER: Gao A 

PROVIDER: S-EPMC7929805 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature