Changes in gastric mucosal microbiota in gastric carcinogenesis: a systematic review protocol.

ABSTRACT:

Introduction

The human stomach is a complex and diverse microbial ecosystem. Consecutive alternations of gastric microbiota occur in gastric carcinogenesis, while the changing pattern during this process remains controversial across studies. We aim to identify the changes in the diversity and composition of gastric mucosal microbiota in gastric tumorigenesis.

Methods and analysis

We will search through PubMed, EMBASE and Cochrane databases, as well as conference proceedings and references of review articles for observational articles reporting either the relative abundance of bacteria at the phylum or genus level or at least one of the alpha diversity indexes respectively and clearly in both gastric cancer and non-cancer groups. Selection of studies and data extraction will

SUBMITTER: Ji R 

PROVIDER: S-EPMC7929888 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature