A Meta-Analysis of the Effect of Bacillus Calmette-Guerin Vaccination Against Bovine Tuberculosis: Is Perfect the Enemy of Good?

ABSTRACT: More than 50 million cattle are likely exposed to bovine tuberculosis (bTB) worldwide, highlighting an urgent need for bTB control strategies in low- and middle-income countries (LMICs) and other regions where the disease remains endemic and test-and-slaughter approaches are unfeasible. While Bacillus Calmette-Guérin (BCG) was first developed as a vaccine for use in cattle even before its widespread use in humans, its efficacy against bTB remains poorly understood. To address this important knowledge gap, we conducted a systematic review and meta-analysis to determine the direct efficacy of BCG against bTB challenge in cattle, and performed scenario analyses with transmission dynamic models incorporating direct and indirect vaccinal effects ("herd-immunity") to assess potential impact on h

SUBMITTER: Srinivasan S 

PROVIDER: S-EPMC7930010 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature