Pharmacotherapeutic strategies for treating cocaine use disorder-what do we have to offer?

ABSTRACT:

Background

Cocaine use contines to be a significant public health problem world-wide. However, despite substantial research efforts, no pharmacotherapies are approved for the treatment of cocaine use disorder (CUD).

Argument

Studies have identified positive signals for a range of medications for treating CUD. These include long-acting amphetamine formulations, modafinil, topiramate, doxazosin and combined topiramate and mixed amphetamine salts extended-release (MAS-ER). However, valid conclusions about a medication's clinical efficacy require nuanced approaches that take into account behavioural phenotypes of the target population (frequency of use, co-abuse of cocaine and other substances, genetic subgroups, psychiatric comorbidity), variables related to the medication (dos

SUBMITTER: Brandt L 

PROVIDER: S-EPMC7930140 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature