Birth Weight Is a Significant Predictor of Retinal Nerve Fiber Layer Thickness at 36 Weeks Postmenstrual Age in Preterm Infants.

ABSTRACT:

Purpose

To assess retinal nerve fiber layer (RNFL) thickness in preterm infants.

Design

Prospective observational study.

Methods

We imaged 83 awake infants (159 eyes) at 36 ± 1 weeks postmenstrual age (defined as the time elapsed between the first day of the last maternal menstrual period and the time at imaging) using a handheld optical coherence tomography (OCT) system at the bedside. Blinded graders semi-automatically segmented RNFL in the papillomacular bundle (-15 to +15° relative to the fovea-optic nerve axis). We correlated RNFL thickness and 7 characteristics of interest (sex, race, ethnicity, gestational age, birth weight, stage of retinopathy at prematurity, and presence of pre-plus or plus disease) via univariable and multivariable regressions.

Results</

SUBMITTER: Shen LL 

PROVIDER: S-EPMC7930155 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature