T-cell CX3CR1 expression as a dynamic blood-based biomarker of response to immune checkpoint inhibitors.

ABSTRACT: Immune checkpoint inhibitors (ICI) have revolutionized treatment for various cancers; however, durable response is limited to only a subset of patients. Discovery of blood-based biomarkers that reflect dynamic change of the tumor microenvironment, and predict response to ICI, will markedly improve current treatment regimens. Here, we investigate CX3C chemokine receptor 1 (CX3CR1), a marker of T-cell differentiation, as a predictive correlate of response to ICI therapy. Successful treatment of tumor-bearing mice with ICI increases the frequency and T-cell receptor clonality of the peripheral CX3CR1⁺CD8⁺ T-cell subset that includes an enriched repertoire of tumor-specific and tumor-infiltrating CD8⁺ T cells. Furthermore, an increase in the frequency of the CX

SUBMITTER: Yamauchi T 

PROVIDER: S-EPMC7930182 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature