Endothelial Regulation by Exogenous Annexin A1 in Inflammatory Response and BBB Integrity Following Traumatic Brain Injury.

ABSTRACT:

Background and target

Following brain trauma, blood-brain barrier (BBB) disruption and inflammatory response are critical pathological steps contributing to secondary injury, leading to high mortality and morbidity. Both pathologies are closely associated with endothelial remodeling. In the present study, we concentrated on annexin A1 (ANXA1) as a novel regulator of endothelial function after traumatic brain injury.

Methods

After establishing controlled cortical impact (CCI) model in male mice, human recombinant ANXA1 (rANXA1) was administered intravenously, followed by assessments of BBB integrity, brain edema, inflammatory response, and neurological deficits.

Result

Animals treated with rANXA1 (1 μg/kg) at 1 h after CCI exhibited optimal BBB protection including all

SUBMITTER: Liu H 

PROVIDER: S-EPMC7930239 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature