Blood pressure variability is related to faster cognitive decline in ischemic stroke patients: PICASSO subanalysis.

ABSTRACT: Blood pressure variability (BPV) is associated with higher cardiovascular morbidity risks; however, its association with cognitive decline remains unclear. We investigated whether higher BPV is associated with faster declines in cognitive function in ischemic stroke (IS) patients. Cognitive function was evaluated between April 2010 and August 2015 using the Mini-mental State Examination (MMSE) and Montreal Cognitive Assessment in 1,240 Korean PICASSO participants. Patients for whom baseline and follow-up cognitive test results and at least five valid BP readings were available were included. A restricted maximum likelihood-based Mixed Model for Repeated Measures was used to compare changes in cognitive function over time. Among a total of 746 participants (64.6 ± 10.8 years; 35.9% female).

SUBMITTER: Kim Y 

PROVIDER: S-EPMC7930263 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature