Epigallocatechin 3-gallate inhibits the plasma membrane Ca²⁺-ATPase: effects on calcium homeostasis.

ABSTRACT: Flavonoids are natural compounds responsible for the health benefits of green tea. Some of the flavonoids present in green tea are catechins, among which are: epigallocatechin, epicatechin-3-gallate, epicatechin, catechin and epigallocatechin-3-gallate (EGCG). The latter was found to induce apoptosis, reduce reactive oxygen species, in some conditions though in others it acts as an oxidizing agent, induce cell cycle arrest, and inhibit carcinogenesis. EGCG also was found to be involved in calcium (Ca²⁺) homeostasis in excitable and in non-excitable cells. In this study, we investigate the effect of catechins on plasma membrane Ca²⁺-ATPase (PMCA), which is one of the main mechanisms that extrude Ca²⁺ out of the cell. Our studies comprised experiments on the

SUBMITTER: Rinaldi DE 

PROVIDER: S-EPMC7930289 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature