The Cholinergic System Contributes to the Immunopathological Progression of Experimental Pulmonary Tuberculosis.

ABSTRACT: The cholinergic system is present in both bacteria and mammals and regulates inflammation during bacterial respiratory infections through neuronal and non-neuronal production of acetylcholine (ACh) and its receptors. However, the presence of this system during the immunopathogenesis of pulmonary tuberculosis (TB) in vivo and in its causative agent Mycobacterium tuberculosis (Mtb) has not been studied. Therefore, we used an experimental model of progressive pulmonary TB in BALB/c mice to quantify pulmonary ACh using high-performance liquid chromatography during the course of the disease. In addition, we performed immunohistochemistry in lung tissue to determine the cellular expression of cholinergic system components, and then administered nicotinic receptor (nAChR) ant

SUBMITTER: Islas-Weinstein L 

PROVIDER: S-EPMC7930380 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature