Exosome-Derived Mediators as Potential Biomarkers for Cardiovascular Diseases: A Network Approach.

ABSTRACT: Cardiovascular diseases (CVDs) are widely recognized as the leading cause of mortality worldwide. Despite the advances in clinical management over the past decades, the underlying pathological mechanisms remain largely unknown. Exosomes have drawn the attention of researchers for their relevance in intercellular communication under both physiological and pathological conditions. These vesicles are suggested as complementary prospective biomarkers of CVDs; however, the role of exosomes in CVDs is still not fully elucidated. Here, we performed a literature search on exosomal biogenesis, characteristics, and functions, as well as the different available exosomal isolation techniques. Moreover, aiming to give new insights into the interaction between exosomes and CVDs, network analysis on the

SUBMITTER: Moreira-Costa L 

PROVIDER: S-EPMC7930981 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature