Cytochrome c Oxidase at Full Thrust: Regulation and Biological Consequences to Flying Insects.

ABSTRACT: Flight dispersal represents a key aspect of the evolutionary and ecological success of insects, allowing escape from predators, mating, and colonization of new niches. The huge energy demand posed by flight activity is essentially met by oxidative phosphorylation (OXPHOS) in flight muscle mitochondria. In insects, mitochondrial ATP supply and oxidant production are regulated by several factors, including the energy demand exerted by changes in adenylate balance. Indeed, adenylate directly regulates OXPHOS by targeting both chemiosmotic ATP production and the activities of specific mitochondrial enzymes. In several organisms, cytochrome c oxidase (COX) is regulated at transcriptional, post-translational, and allosteric levels, impacting mitochondrial energy metabolism, and redox balance. Th

SUBMITTER: Mesquita RD 

PROVIDER: S-EPMC7931083 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature