Exoproteome Perspective on the Bile Stress Response of Lactobacillus johnsonii.

ABSTRACT: Probiotics must not only exert a health-promoting effect but also be capable of adapting to the harsh environment of the gastrointestinal (GI) tract. Probiotics in the GI tract must survive the cell wall-disrupting effect of bile acids. We investigated the exoproteome of Lactobacillus johnsonii PF01 and C1-10 under bile stress. A comparative analysis revealed the similarities between the two L. johnsonii exoproteomes, as well as their different responses to bile. The large number of metabolic proteins in L. johnsonii revealed its metabolic adaptation to meet protein synthesis requirements under bile stress. In addition, cell wall modifications occurred in response to bile. Furthermore, some extracellular proteins of L. johnsonii may have moo

SUBMITTER: Bagon BB 

PROVIDER: S-EPMC7931105 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature