Safety evaluation of the food enzyme endo-1,3(4)-β-glucanase from the genetically modified Bacillus subtilis strain DP-Ezm28.

ABSTRACT: The food enzyme endo-1,3(4)-β-glucanase (3(or 4)-β-d-glucan 3(4)-glucanohydrolase; EC 3.2.1.6) is produced with a genetically modified Bacillus subtilis strain DP-Ezm28 by Danisco US Inc. The genetic modifications do not give rise to safety concerns. The production strain of the food enzyme contains multiple copies of a known antimicrobial resistance gene. However, based on the absence of viable cells and DNA from the production organism in the food enzyme, this is not considered to be a risk. The food enzyme is intended to be used in distilled alcohol production and brewing processes. Since residual amounts of total organic solids (TOS) are removed by distillation, dietary exposure was only calculated for brewing processes. Based on the maximum use levels recommended for brewing pr

SUBMITTER: EFSA Panel on Food Contact Materials, Enzymes, Processing Aids (CEP) 

PROVIDER: S-EPMC7931123 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature